E. Jane Albert Hubbard Lab
Developmental and physiological control of
stem and progenitor cells in vivo.
Stem cells are important for organ growth and maintenance of tissues and organs. We wish to understand the cellular and molecular mechanisms that influence the establishment, behavior, and maintenance of stem and progenitor cells.
We study the developmental and physiological control of germline stem cell establishment, maintenance, proliferation and differentiation in C. elegans. We take advantage of the molecular genetics and imaging available in this relatively simple worm to study aspects of stem cell biology that are conserved among all organisms.
Our recent work uncovered links between the nutritional and sensory status and the expansion of the progenitor pool during development. Environmental cues act together with the Notch signaling pathway to maintain germline stem cells. We are also developing tools to monitor and model stem cell dynamics in vivo and in silico, respectively.